Influence of acetaminophen and trichloroethylene on liver cytochrome P450-dependent monooxygenase system.
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منابع مشابه
Influence of acetaminophen and trichloroethylene on liver cytochrome P450-dependent monooxygenase system.
The aim of the study was to evaluate the effect of acetaminophen (APAP) and/or trichloroethylene (TRI) on the liver cytochrome P450-dependent monooxygenase system, CYP2E1 and CYP1A2 (two important P450 isoforms), and liver glutathione (GSH) content in rats. Rats were given three different doses of APAP (250, 500 and 1000 mg/kg b...) and then the above-mentioned parameters were measured for 48 h...
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Flavonoids are widely occurring in our diet. In this study, the effects of nine flavonoids on acetaminophen (APAP) oxidation and related cytochrome P450 (P450) enzyme activities were investigated. With rat liver microsomes, APAP oxidation was stimulated 2- to 4-fold by 50 microM flavone or tangeretin and inhibited 65% by myricetin or quercetin. Only a slight inhibition of APAP oxidation was cau...
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ژورنال
عنوان ژورنال: Acta Biochimica Polonica
سال: 2000
ISSN: 1734-154X,0001-527X
DOI: 10.18388/abp.2000_3965